It's going to be a tough game- I'd feel much better if we were playing at home. I don't bet individual games, but if I did, I wouldn't touch this game. So many variables in play. However, if someone forced me to make a pick, I'd probably go with Duke. Never easy for a QB to make his first road start, especially against a respectable opponent like Duke.
That being said, this game is very winnable for NU. To me, it will come down to limiting turnovers (no more than one), and how our d-line does against the Duke o-line. That is one area where it looks like we have a pretty big edge as it is not one of their stronger groups, and it is arguably the strongest unit on our entire team. I am confident we will get pressure, but we have to make sure we actually get some of the sacks, and contain the Duke QB, who does have the ability to scramble. I also think that our secondary could pose problems for a Duke QB that has ability, but hasn't faced a quality defense yet. Our passing game is going to have to show a dynamic that it hasn't shown yet as well (IMO). I'm not saying we have to be slinging it all over the place, but I think we need to stretch the field a little bit more so Duke has to at least respect the mid/deep ball and doesn't put 8-9 guys in the box the entire game.