Injuries, to some degree, are a by-product of depth and how you use your bench.
Many other factors, of course. Luck being one of them, but also how you practice, how you play defense, all kinds of things.
I think most would agree that tired players are somewhat more likely to get hurt.
And there's the simple math of it. Assuming there's a tiny likelihood of getting injured for every minute you play, the more it behooves you (haven't used that word in a decade or two) to rest your starters when you can.
Last year we saw this - it was anticipated/feared by quite a few on this message board because everybody saw how we had only 5 guys to play 4 positions. The shocking thing was that we had unused guys on our bench who were able to come in and play competitively, so that the impact wasn't as painful as we had feared when Berry was lost for the season and Langborg missed some time.